| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | | | b. Abt 1856 | d. Yes, date unknown | Dr. George McClain Spencer, M.D. | Martha A. Crawford |
| 2 | | | b. 7 Mar 1859 | d. May 1957 | Dr. George McClain Spencer, M.D. | Martha A. Crawford |
| 3 | Yes | | b. 1863 | d. 1947 | Dr. George McClain Spencer, M.D. | Martha A. Crawford |
| 4 | | | b. Abt 1869 | d. 1946 | Dr. George McClain Spencer, M.D. | Nancy Crawford |
| 5 | | | b. Abt 1871 | d. 1954 | Dr. George McClain Spencer, M.D. | Nancy Crawford |
| 6 | | | b. Abt 1873 | d. 1926 | Dr. George McClain Spencer, M.D. | Nancy Crawford |
| 7 | | | b. Abt 1876 | d. 1950 | Dr. George McClain Spencer, M.D. | Nancy Crawford |
| 8 | | | b. Abt 1878 | d. 1958 | Dr. George McClain Spencer, M.D. | Nancy Crawford |
| 9 | | | b. Abt 1880 | d. 1958 | Dr. George McClain Spencer, M.D. | Nancy Crawford |
| 10 | | | b. Feb 1882 | d. 1917 | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 11 | | | b. Abt 1884 | d. Stillborn | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 12 | | | b. Apr 1885 | d. 1954 | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 13 | | | b. Oct 1887 | d. 1944 | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 14 | | | b. Dec 1889 | d. 1939 | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 15 | | | b. Abt 1892 | d. Bef 1900 | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 16 | | | b. Abt 1894 | d. Bef 1900 | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 17 | | | b. Oct 1896 | d. Yes, date unknown | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 18 | | | b. Jan 1899 | d. Yes, date unknown | Dr. George McClain Spencer, M.D. | Ella Mayes |
| 19 | | | b. Abt 1901 | d. Bef 1910 | Dr. George McClain Spencer, M.D. | Ella Mayes |
1831 - 1921 (89 years)