
| 1st Lord Semple John Semple | |
| D: | 9 Sep 1513 |
| Flodden, Scotland | |
| Margaret Colvill | |
| M: | Bef 9 Sep 1501 |
| Flodden, Scotland | |
| 4th of Caldwell Adam Mure | |
| M: | Caldwell, Scotland |
| D: | Bef 1516 |
| Caldwell, Scotland | |
| Thomas Semple | |
| D: | 11 Jun 1488 |
| Sauchieburn, Scotland | |
| Elizabeth Ross | |
| M: | Sauchieburn, Scotland |
| D: | Bef 17 Nov 1505 |
| Sauchieburn, Scotland | |
| William Semple | |
| B: | 1415 |
| Elliotstoun, Scotland | |
| D: | Yes, date unknown |
| Margaret Cathcart | |
| B: | 1425 |
| Renfrewshire, Scotland | |
| M: | Elliotstoun, Scotland |
| D: | Yes, date unknown |
| Robert Semple | |
| B: | Elliotstoun, Scotland |
| M: | Elliotstoun, Scotland |
| D: | 1478 |
| Elliotstoun, Scotland | |