| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | Yes | | b. 16 Nov 1774 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 2 | | | b. 25 Feb 1776 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 3 | | | b. 10 Oct 1778 | d. Between 1856 and 1857 | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 4 | | | b. 27 Sep 1780 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 5 | | | b. 2 Mar 1784 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 6 | | | b. 7 May 1785 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 7 | | | b. 7 May 1787 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
| 8 | Yes | | b. 22 Oct 1789 | d. Yes, date unknown | Dr. Ezekiel Alexander, MD (Sr) | Jemima Esther McCoy |
1754 - 1832 (77 years)